Tough Love Essay Example for Free

Tough Love Essay â€Å"If you have to make a choice, to be feared is much safer than to be loved† (46). Niccolà ² Machiavelli declared this in The Prince while explaining how to be an extraordinary leader. If leaders are feared they will be respected by their people and other countries, thus keeping justice and maintaining control. If a leader is feared, they will receive respect from their people and other countries. People will not turn against the leader, but if the people love him they would willingly take advantage of him. Likewise, if a country is in fear of a certain leader or country they would never think of turning against or taking advantage of them. As Niccolà ² Machiavelli stated in The Prince, â€Å"People are less concerned with offending a man who makes himself loved than one who makes himself feared; the reason Is that love is a link of obligation which men, because they are rotten, will break any time they think doing so serves their advantage; but fear involves dread of punishment, form which they can never escape† (46). Feared leaders can preserve justice in their country. Machiavelli declared, â€Å"†¦Hannibal†¦ having an immense army, which included men of many different races and nations, and which he led to battle in distant countries, he never allowed them to fight among themselves or to rise against him, whether his fortune was good or bad. The reason for this could only be his inhuman cruelty, which, along with his countless other talents†¦ without the cruelty, his other qualities would never have sufficed† (46-47). This leader used forms of cruelty to instill a feeling of fear in his people. His people lived in apprehension of all injustice to avoid penalty many times defined as death. People will be less likely to act out against or try to over throw their leader if they are afraid of him. Above all, one will be able to effectively maintain control over his people and various other countries. The people will follow their leader in whatever situation takes place. However, if the people loved their leader, they would not feel guilt or remorse in disobeying their leader; therefore  he does not have a complete control over his people. This could result in chaos. Armies who fear their leader will do what the leader feels is necessary or called for, in order to avoid crossing him. Similarly to what is said of his people, other countries would not attack or try to overthrow the leader. Countries would rather ally with a feared country or leader, because of this weaker countries that ally with the leader could than fall under control of the leader. Once a country, its people, and other countries fear a leader, he will have complete power over them and they would give themselves to him to avoid punishment. When the leader has control he will easily be able to uphold righteousness and justice. When one fears an authority figure it is because they know that if they happen to do wrong that authority figure will not think twice before putting us in our place or chastising us. Works Cited Machiavelli, Niccolà ². The Prince. Trans. Robert M. Adams. New York: Norton, 1992.

Carbonic Anhydrase The Fastest Enzyme Biology Essay

Carbonic Anhydrase The Fastest Enzyme Biology Essay Carbonic anhydrase, abbreviated as CA, is the first identified zinc containing enzyme, (CA; carbonate hydro-lyase, EC 4.2.1.1) It is an enzyme that catalyzes the reversible hydration and dehydration of carbon dioxide to form carbonic acid, bicarbonate ions and protons. Being one of the fastest enzyme known, it is believed that one molecule of CA can process one million molecules of carbon dioxide  per second. The basic molecular structure of CA includes specific amino acid threonine 199, glutamate 106, histidine 64 and histidine residues namely His 93, His 95, and His 118. The mode of regulation of CA is being inhibited by various medically prescribed substances that act as non competitive inhibitors, an example is Acetazolamide. CA plays a major key role in the fluid balance and regulatory of pH in different parts of the body thus, Mutation of this enzyme may lead to several diseases.(1) CARBONIC ANYHYDRASE THE START: Breathing, a fundamental function in life The air that we breathe in has some valuable oxygen, an important molecule wherein it helps the breakdown of fats and sugars in our cells. From the blood, oxygen diffuses then binds with the hemoglobin to be transported in the cells of our body. A by product of sugar and fat breakdown in cells is called Carbon dioxide CO2). It is a key metabolite in all living organism and it needs to be removed from our body. Carbon dioxide is diffuse out of the cells and transported in the blood in different ways to get to the lungs. CA is transported in numerous forms, mainly as bicarbonate, HCO3-. Bicarbonate is a CO2- with an attached OH group. When the HCO3- reaches the lungs, it is transformed back to a CO2, so it can be exhaled from the body. The conversion of bicarbonate to carbon dioxide facilitates its transport into the cell; while the conversion of carbon dioxide to bicarbonate assists trap the carbon dioxide in the cell. This interconversion of carbon dioxide and bicarbonate develop at a slow physiological pH hence organism tend to produces an enzyme to hasten the process. This enzyme responsible for the speed up interconversion, which can be found in the red blood cells, is called carbonic anhydrase. Although the interconversion of bicarbonate to carbon dioxide can happen without the enzyme, CA can great increase the rate of the conversions up to a millions of fold. (2) STRUCTURE The CA molecule in general has ellipsoidal shape with the estimated dimension 4.1 x 4.1 x 4.7 nm. The active site is situated in a cavity having an approximately conical shape. The cavity is assessed 1.5 m wide at the way in and about 1.6 nm deep attaining almost the center of the molecule. The zinc ion is next to the peak of the cone and liganded into 3 imidazole groups. Figure 1. CA Structure (2) Figure 1. shows the structure of CA. Taken as a whole, is composed of 10-stranded anti-parallel beta-sheet enclosed with various elements of other secondary structure. The 6 alpha-helices and 10-beta sheets make up the secondary structure of carbonic anhydrase. The basic function of CA is basically to regulate the oxygen and carbon dioxide content of the blood that is needed in a human body. As the function suggests, the chemical structure of CA extremely lies with the presence of zinc that lies deep within its active site. Its common amino acid composition includes threonine, glutamate and histidine. The specificity of these 3 amino acids (threonine 199, glutamate 106, and histidine 64) plays a critical role in relation to the presence of zinc by charging it with a hydroxyl ion. The zinc cation is associated with three histidine residue protein backbone namely: His93, His95, and His118. As stated, zinc plays a major role in the reaction of CA. The zinc present in the active side of CA is being bound to water to be able to dissociate it into a proton and hydroxyl ion. The hydroxyl ion is being stabilized by the positively charged zinc, in this way; the hydroxyl ion is being prepared to attack the carbon dioxide inside the RBC. A closer look with CA can be seen in the figure below where the amino acid chains in the active site together with the zinc are evident. The role of the zinc basically includes the command of directional transfer of the bound hydroxyl to the carbon dioxide to be able to form bicarbonate ion. From the figure, it shows that the intermediate structure where the bicarbonate ion is still attached to the enzyme. The alanine replicated the side chain for amino acid 199 in this arrangement. Histidine 64 swings in the direction of and away from the zinc ion in every cycle of enzyme action although it is helping the zinc to recharge with a novel hydroxyl ion. The two locations of this residue, revealed in the bottom right figure, symbolize its movement throughout the action of enzyme. Almost immediately as the zinc is reloaded with an original water molecule together with the release of bicarbonate ion, the enzyme is set for another action on some new carbon dioxide molecule. (3) MECHANISM OF CATALYSIS The rate of catalysis of the CA is exceedingly pH dependent. It means that, the higher the pH, the catalysis is faster and as the pH reduces, the speed of the reaction falls down. The mean pH of this transition is near pH 7. (5) Figure 2. Mechanism of CA catalysis (6) Figure 2.0 shows the mechanism of CA catalysis. A zinc atom which is generally bound to four or more ligands differs in CA. In CA, three locations are occupied by imidazole ring of three histidine residues and an additional site is occupied by a water molecule. Thus the geometry form of the active site is tetrahedral. The zinc atom plays an important role in the mechanism of CA catalysis because it is responsible for the release of a proton H+ from a water molecule, which then generates a nucleophilic hydroxide ion. Then the carbon dioxide substrate will attach to the active site of the enzyme to react with the ion of hydroxide. The zinc-bound OH-  attacks the carbon of CO2  therefore converting it into a bicarbonate ion. This occurs since the zinc ion has the +2 charge, which attracts the oxygen of water. It then deprotonates the water, thus, converting it into a better nucleophile so that the newly converted hydroxyl ion can attack the carbon dioxide. After the nucleophilic att ack of zinc bound OH-, addition of water molecule displaces the bicarbonate ion from the metal ion. The CA is then ready for another cycle of catalysis. (7) KINETICS OF REACTIONS CA inhibitors are class of pharmaceuticals that control the activity of carbonic anhydrase. It is inhibited by two classes of compounds, a metal complex forming anions and others are isosteres and sulfonamides. Inhibitors ionize upon binding with the enzyme to give way an NH- group that relocates the zinc hydroxide ions and shares a hydrogen bond. There are roughly 25 clinically used CA inhibitors as a drugs. It is mainly established as antiglaucoma drugs, diuretics, hypotensive agents, anticonvulsants, anticancer agents, antiepileptics, with additional use in the management of duodenal and gastric ulcers, osteoporosis and neurological disorder. (8) Acetazolamide Methazolamide Dorzolamide Topiramate Figure 3. Illustrations of some CA inhibitors (9) Figure 3.0 shows some CA inhibitors like Acetozolamide which acts as a mild diuretic. It cures glaucoma, altitude sickness, and some benign intracranial hypertension. Methazolamide treats glaucoma present in dogs which is called Open-angle glaucoma. While Topiramate which is a weak inhibitor, alleviate epilepsy, lennox gastuat syndrome and migraine headaches. And another CA inhibitor is the, Dorzolamide or sulphonamide which treat ocular hypertension or open-angele glaucoma. (10) CA activator regulates the proton transfer processes between the active site and the solvent system. It also binds at the entrance of the enzyme of the active site. One of the strong activator of CA is Histidine. Some amines and amino acids like l-Trp (tryptophan), l-Phe (Phenylalanine),  d-DOPA (D- 3,4-dihydroxyphenylalanine),  l-Tyr (Tyrosine), 4-amino-l-Phe also works as activators of CA. These CA activators are potentially target for drug development that can be useful as a derivative for the enhancement of synaptic efficacy which can be able to treat various conditions like, depression, alzheimers disease, ageing, spatial learning and memory therapy enhancer. (11) MODE OF REGULATION: Acetazolamide Inhibitor In case of excessive contents of CA in blood and peripheral areas of the lungs, proper regulation and inhibition is needed. Acetazolamide is a non competitive inhibitor that is effective in giving control with the catalytic reaction of the enzyme. This chemical complex substance is medically used o treat different conditions of moderate up to severe metabolic or respiratory alkalosis. Alkalosis may happen if excess CA is being reacted with the bicarbonate and carbon dioxide ions in the RBC, causing extreme absorption of bicarbonate thus giving the erythrocyte more basicity rather than having enough and sufficient pH level. Acetazolamide action is explained by interfering with bicarbonate (HCO3-) reabsorption in the kidneys, thereby giving enough acidity in the RBC, and further results to alkalinizing the urine. The action of inhibition results further to decreased synthesis of aqueous humor of the eye and causes the lowering of intraocular pressure. The interaction of Acetazolamide with CA does not occur with the active site, only close or remote to the active site. The net effect of this inhibitor basically changes the shape of CA that obviously leads to the inability of the substrate to bind properly, results to no catalytic reaction. (12) CARBONIC ANHYDRASE IN HEALTH AND DISEASE: Carbonic Anhydrase is found in numerous places in the body, including in the cerebro-spinal fluid, cytosol of some cells and mainly in the red blood cells. Since CA generates and utilizes protons and bicarbonate ions, it plays a major key role in the fluid balance and regulatory of pH in different parts of the body. Absence or mutation of the CA enzyme may lead to several diseases.  Also, CA inhibitor contributes to several treatments of diseases. One of the linked diseases of CA is the Osteopetrosis with cerebral calcification and renal acidosis. It is a syndrome deficient with CA in the body commonly called as Marble brain disease. This happens because sulfonamide inhibitor of CA can produce metabolic acidosis and have shown that CA inhibitors blocks the parathyroid hormone-induced the release of calcium bone which causes bone resorption. And since CA is present in the brain and CA inhibitors inhibits the production of cerebral spinal fluid, mutation of CA lead to cerebral calcification. Other disease associated with the deficiency of specific type of CAIII is the Myastenia gravis. It is an autoimmune neuromuscular disorder that results to a weak muscle of a person. Defects in CA IV can cause retinitis pigmentosa, a degeneration of retinal photoreceptor, which a patient experiences night vision blindness and loss of midperipheral visual. (13) Glaucoma, a condition wherein a build up of fluid in the eyes occurs and this presses the optic nerve that caused damage, is treated with the use of CA inhibitors like acetazolamide, brinzolamide, dorzolamide, and methazolamide. These inhibitors lessen the amount of fluid in the eye rapidly by 40% to 60% thus lowering the pressure inside the eye of a person with glaucoma. It now lessens the risk of optic nerve damage which promote vision loss. But prolong use of this drug affects the same enzyme in the tissue and may lead to kidney and liver damage The CA also plays an important role in the secretion of acid through the catalyzed hydration of excreted CO2 in the stomach lining which is mainly responsible in digestion of food. It helps to make pancreatic juice alkaline and our saliva neutral. In summary, CA performs different role and functions at their specific locations. (14)

Remarks on the Spoudaios in Plotinus Essay -- Ethics Philosophy Papers

Remarks on the Spoudaios in Plotinus Who is the Plotinian spoudaios and what is his function in the Enneads? This question turns out to be fundamental, especially when trying to make out an ethical dimension in Plotinus. Treatise I 4 [46] offers, concerning that question, not only the longest sustained discussion of the spoudaios, but also shows how highly problematic it is to figure out more precisely his characteristics. This is due to the terminological ambiguity with the term sophos, which is also the reason why the two terms are often considered synonymous by translators. It appears in I 4 that this ambiguity is closely related to the question of aisthesis. And this is also perhaps the main problematic point concerning the spoudaios: he is instituted by Plotinus as the paradigm of the ‘living man,’ but is still described as someone who has detached himself from the bounds of the sensible world. So this leads to several conclusions concerning the Plotinian conception of ethical implication. 1. status questionis Who is the plotinian spoudaios and what is his function in the Enneads? This question occurs especially in regard to treatise I 4 [46] which offers the longest sustained discussion of the spoudaios. The main problem which presents itself as regards the term spoudaios is its apparent terminological similarity with sophos. As most translations show, both terms seem to be taken as almost synonymous, the most problematic one being Brà ©hier's French translation of the Enneads where spoudaios and sophos figure as the wise (le sage). This has mainly to do with the tradition of the term of spoudaios, as will be shown further on. What I would like to show in this paper is that the function of the spoudaios has b... ...ry similar formulation in the pseudoplatonic Definitions: "spoudaios: o teleios agathos; ho echon ten autou areten "(415e). (10) Even though within the three Ethics the status of the spoudaios turns out not to be totally equivalent. It is not possible to discuss further this point, as it would lead to considerations which go beyond the purpose of this paper. (11) NE III, 1113a32-33. (12) H. v. Arnim, Stoicorum veterum fragmenta, Teubner, Stuttgart, 1964, vol. III. (13) In Philo, vol. IX, trad. Colson, p. 10-100. (14) Which is the Henry-Schwyzer version, while Armstrong and Brà ©hier read: "kan spoudaios e autarkes†¦" (15) Which is the classic argument since Aristotle, NE, I. 10. 1100a8 and 11. 1101a8. (16) All quotations are from Armstrongs translation, whereas I keep the Greek terms for spoudaios and sophos, so to avoid further ambiguities.

Animal Emotions Essay -- essays papers

Animal Emotions Do animals feel joy, love, fear, anguish or despair? What ere emotions, and perhaps more importantly, how do scientists prove animals are capable of emotion? Sea lion mothers have often been seen wailing painfully and squealing eerily as they watch their babies being eaten by killer whales. Buffaloes have also been observed sliding playfully across ice, excitedly screaming â€Å"Gwaaa.† Emotions are defined broadly as psychological phenomena that help in behavioral management and control. This is a challenging question to researchers who are trying to determine the answer to this question. Through current research by close observation combined with neurobiological research, evidence that animals exhibit fear, joy happiness, shame, embarrassment, resentment, jealousy, rage, anger, love, pleasure, compassion, respect, relief, disgust, sadness, despair, and grief is likely. Charles Darwin said, â€Å"The lower animals, like man, manifestly feel pleasure and pain, happines s, and misery.† I agree with Darwin. I believe animals do exhibit emotions, and denying that animals have emotions because the subject cannot be studied directly is not a reasonable explanation. One recent headline in the news showed an extraordinary event on film. When a three-year-old boy fell into a gorilla enclosure at the zoo, and was knocked unconscious. A female Gorilla named Binti Jua picked up the boy, and cradled him in her arms as if he was her own. The gorilla then gently carried the boy over to the caretaker’s door and set him down. Did the gorilla feel empathy for the boy? By watching the film alone the gorilla seemed to show emotions for the boy, but without studying the animal neurobiologically scientists cannot understand how her emotions and cognitions were linked. One scientist, Damasio, provided an explanation how emotions can be felt in humans biologically. Damasio suggested, â€Å"Various brain structures map both the organism and external objects to create what he calls a second order representation. This mapping of the organism and the object most likely occurs in the thalamus and cingulate cortices. A sense of self in the act of knowing is created, and the individual knows â€Å"to whom this is happening.† The â€Å"seer† and the â€Å"seen,† the â€Å"thought† and the â€Å"thinker† are one in the same.† By mapping the brain scientists can have a better understandi... ...ung children. He said â€Å"A greylag goose that has lost its partner shows all the symptoms that John Bowlby has described in young human children in his famous book Infant Grief. . . the eyes sink deep into their sockets, and the individual has an overall drooping experience, literally letting their head hang.† Elephants stand guard over a stillborn baby for days with their head and their ears hanging down like they were sad. The experiments and other data show that animals are not just driven by instincts alone. There is more to them than that. It is hard to watch dogs play and believe that they derive no fun or pleasure from it at all. Animals have shown that they are sensitive to their social surroundings. They punish one another and alleviate other’s pain. Some monkeys in established communities attack those that find food and don’t share. These studies are important. A better understanding of how animals are feeling could create a whole new guideline of rules on the way animals should be treated. Humans should not be so arrogant to believe they are the only animals capable of emotion. How are we capable of seeing from their viewpoint and assume they feel no emotion.

Alcohol Essay -- essays research papers

Giovanni Vaccarello, a retired machinist form Brooklyn, New York, never took the safety of his family for granted. He often drove Maria, 18, and Concetta, 17, to their part time jobs. John, his fourteen year old son, was to wear a beeper at all times so that he would never be out of reach. Giovanni routinely walked Cathy, his wife of twenty five years, one block to her job at the beauty salon. But with all the precautions Giovanni took, nothing could stop him from Abraham Meyers, a 25-year-old janitor from Brooklyn. At about 11:30 on May 1, 1994, Giovanni left the Russo’s catering hall in Queens with Cathy, Maria, and Concetta. John lingered behind as the others crossed the street and headed for the car. It was then that Meyers, allegedly going at speeds over 70 mph without headlights on, smashed into them, sending the Vaccarello’s flying. Maria and Concetta died instantly, while Cathy held on for a few hours on life support before dying. Giovanni escaped with his leg broken in three places, but suffered a heart attack that kept him in the hospital for a month. Meyers’ blood alcohol was tested at .2, double the legal limit for driving while intoxicated. This was not the first time he would face charges for driving under the influence of alcohol, he has had his license suspended 26 times and has drunk driving convictions dating back to 1967. Although Meyers kept driving without a license, he never spent one day in jail. He now faces up to life in prison, but this is of no con... Alcohol Essay -- essays research papers Giovanni Vaccarello, a retired machinist form Brooklyn, New York, never took the safety of his family for granted. He often drove Maria, 18, and Concetta, 17, to their part time jobs. John, his fourteen year old son, was to wear a beeper at all times so that he would never be out of reach. Giovanni routinely walked Cathy, his wife of twenty five years, one block to her job at the beauty salon. But with all the precautions Giovanni took, nothing could stop him from Abraham Meyers, a 25-year-old janitor from Brooklyn. At about 11:30 on May 1, 1994, Giovanni left the Russo’s catering hall in Queens with Cathy, Maria, and Concetta. John lingered behind as the others crossed the street and headed for the car. It was then that Meyers, allegedly going at speeds over 70 mph without headlights on, smashed into them, sending the Vaccarello’s flying. Maria and Concetta died instantly, while Cathy held on for a few hours on life support before dying. Giovanni escaped with his leg broken in three places, but suffered a heart attack that kept him in the hospital for a month. Meyers’ blood alcohol was tested at .2, double the legal limit for driving while intoxicated. This was not the first time he would face charges for driving under the influence of alcohol, he has had his license suspended 26 times and has drunk driving convictions dating back to 1967. Although Meyers kept driving without a license, he never spent one day in jail. He now faces up to life in prison, but this is of no con...

Effects of economy of the United States Essay

The cost of advancing economy of the United States is highly dependent on the Gross Domestic Product. This refers to the level of production nationals of a country and the production by the foreigners in the country. The main determinates of the countries production is the levels of employment and the stability of the government, in that case if the nationals of a specific country are unemployed the economy of the country will be quite low since the unemployed group will not have contribution to the country’s GDP (P. Kooiman p 178). If the economy of the country is quite low the employers tend to impose strategies to down size there work forces, this move will tend to increase the level of unemployment in the country hence even higher losses in the GDP. The concept is a clear illustration of the causes of several countries including the U. S causes of decreasing economic power and increasing levels of unemployment such as the statistics recorded in the year 2000 census. Economic technology determinates Unemployment also affects the economy in the sense that if the unemployment levels decrease the demand of goods and services. In other words the unemployment results to lowering the people’s purchasing power, especially in goods that are considered secondary goods. The unemployment persons reflect a loss in the sales level and level which are the economic power of a country since they are considered liabilities to the economy as they do not contribute to the boosting of the economy or bringing revenue to the country as they do not receive any salary or wage in relation to the work they perform. Hence unemployment weakens the economy since the consumers’ power is stronger than the production levels (Wikipedia encyclopedia). Political technology determinates According to Fred C. Pampel the U. S employment levels are based on the government, his argument is based on the fact that if the government does not maintain a stable country and economic power the people’s employment levels will tend to be quite low. In that case all countries watch out on the government moves to reduce the levels of unemployment by either increasing the job opportunities or by assisting the unemployed with capital for them to start up self employment such as small business. If the government does not do that it’s considered ineffective by the locals and can even be voted out come the next elections (Fred C. Pampel, John B. Williamson p203). In the United States fore example the political readers have taken up the role of reducing the levels of unemployment not only to improve their public image and popularity but also to improve the government strength in carrying out it’s activities. The government’s activities are financed through taxes which are gotten from the public, hence by reducing the levels of unemployment the levels of taxes are increased since the public has higher incomes to be taxed. Conclusion In the United States the military Marine Corps play an important factor in the advancement of technology. The Marine Corps refer to a United States military branch which deals with force projection in water masses such as the sea. The branch carries its activities with the help of the armed task forces and the uniformed service to uphold the mobility of the US navy. The Marine Corps work closely with the US naval forces since the naval forces are considered perfectly trained, on ways of exploiting the available means of transport and techniques used in each. They are therefore associated with improvement of technology since by maximum exploitation of the current resources they find their pros and cons; therefore they tend to improve the current technology through solving the problems related to the current technology. References 1. Gen. Charles C. Krulak (1996). â€Å"Operational Maneuver from the Sea† (PDF). Headquarters Marine Corps 2. P. Kooiman (1986), Some empirical models for markets in disequilibrium, Ph. D. thesis, Erasmus University Rotterdam 3. G. den Broeder (1983), A family of market transaction functions, Foundations of Empirical Economic Research 1983/1, Rotterdam: Netherlands Economic Institute 4. American Journal of Community Psychology, Unemployment and its effects on families: Evidence from a plant closing study – Springer Netherlands (2005) ISSN 0091-0562 (Print) 1573-2770 (Online) 5. Wikipedia the free encyclopedia http://en. wikipedia. org/wiki/Unemployment

Turn of the Screw

Claire Carlson English 3H February 7, 2013 Period 1 Spring Essay: Turn of the Screw Page I: The Governess and Miles Page II: The Governess and Mrs. Grose Page III: Corruption of Innocence Henry James’s Turn of the Screw is the eerie tale of a governess sent to care for two mischievous young children, Flora and Miles. Many people mistake it for a ghost story, but the story actually focuses more on the governess’s relationship with the children. Her thirst for acceptance gradually grows as the story progresses, and she becomes especially fascinated with Miles.Women have always been viewed as slightly inferior to men; they are depicted as weak and fragile creatures, only serving as a companion for man. They are manipulative and often use charm and looks as methods of persuasion. In Turn of the Screw, the governess ‘s attitude while around Miles is flirtatious and almost inappropriate; and she uses him to fill the void of the children’s beloved uncle whom she l usts for. The above example of the governess’s craving for Miles’s attention can be easily compared to the behavior exhibited by much of the female population today.Note that the woman is always seeking to please the man, and strives to satisfy and serve him. The attitude of women in the modern world is becoming more and more submissive; almost voluntarily. Miles’s reaction to the behavior of the unnamed governess is merely compliant, and in some instances of the novel he somewhat encourages her inappropriate behavior. Mrs. Grose, the simpleminded and somewhat slow housekeeper at the estate, represents a middle ground between the mischievous children and whimsical governess. The reader can easily conclude that the governess abuses Mrs.Grose’s quite malleable opinion of the children. In several instances, the governess consults Mrs. Grose and uses her as an outlet for her frustrations with the children. As the governess shares her ghostly encounters with Q uint and Miss Jessel, she convinces Mrs. Grose that her hysteria is justified. Since Mrs. Grose is not significantly talkative, it is difficult to form a conclusion about her opinion of the children and the governess. The reader has to infer that Mrs. Grose has spent quite some time at the estate, and has much experience with the children’s behavior. Mrs.Grose doesn’t necessarily agree or disagree with the statements and assertions made by the governess, she is merely a cache, storing the governess’s thoughts and responding with uncomprehending feedback. The children’s relationship with Mrs. Grose is somewhat distant and peculiar. They only consult her for affirmation and approval. In conclusion, Mrs. Grose is mainly an unresponsive character and is not a major influence on the circumstances of the story. Since the governess seldom approaches the children directly, we can infer that she would rather keep her knowledge of Quint and Jessel to herself.She of ten consults Mrs. Grose in order to gather as much as she can about the two. The governess is afraid that the children know too much, and fears that their knowledge of Quint and Jessel’s sexual relationship will affect them negatively. The fact that she is more concerned about the children knowing too much rather than protecting them from the possible harm that the ghosts can inflict, shows the reader that the governess incorporates her own fears and desires into the situation. In conclusion, Turn of the Screw is a much more complex and confusing story than meets the eye.The reader must question the behavior of the governess and the children in order to gather valuable information about the ghosts, and it seems as though in certain instances that Quint and Jessel are living through Flora and Miles. The governess is indeed a much more questionable character than the book portrays her to be. From my experience with both the book and a movie interpretation of the book, I have co ncluded that the governess is actually the main source of the hysteria and trauma at Bly.